Fioricet is a drug used to treat tension headaches and it combines caffeine, butalbital and acetaminophen.
The latter is used as a fever reducer and pain reliever. The butalbital belongs to the class of drugs known as barbiturates and it relaxes the muscle contractions caused by tension headaches.  
 
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Fioricet Missed Dose

Do not take a double dose of Fioricet. Take the missed dose of Fioricet as soon as you remember. If it is almost time for your next dose, skip the missed dose and go back to taking Fioricet on your regular dosing schedule.

Overdose: Following an acute overdosage of butalbital, acetaminophen, and caffeine, toxicity may result from the barbiturate or the acetaminophen. Toxicity due to caffeine is less likely, due to the relatively small amounts in this formulation.

Signs and Symptoms: Toxicity from barbiturate poisoning include drowsiness, confusion, and coma; respiratory depression; hypotension; and hypovolemic shock.

In acetaminophen overdosage: dose-dependent, potentially fatal hepatic necrosis is the most serious adverse effect. Renal tubular necroses, hypoglycemic coma, and thrombocytopenia may also occur.

Early symptoms following a potentially hepatotoxic overdose may include: nausea, vomiting, diaphoresis, and general malaise. Clinical and laboratory evidence of hepatic toxicity may not be apparent until 48 to 72 hours post-ingestion. In adults hepatic toxicity has rarely been reported with acute overdoses of less than 10 grams, or fatalities with less than 15 grams.

Acute caffeine poisoning may cause insomnia, restlessness, tremor, and delirium, tachycardia and extrasystoles.

 

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